Nano-opening hollow resin spheres with high drug loading capacity and capable of loading macromolecular drugs

Nanocarriers, Nanospheres, Nanoporous carbon spheres, hollow resin spheres

Nanoparticles (Nanoporous carbon spheres/hollow resin spheres) used as drug delivery systems/drug delivery carriers (Nanocarriers, Nanospheres, Nanoporous carbon spheres) are generally submicron particles (3-200nm), including polymers (such as polymer nanoparticles, micelles or dendrimers), lipids (liposomes), proteins (white proteins, transferrin), viruses (viral nanoparticles), organometallic compounds (nanotubes, MOF), and even cell-derived nanoparticles (such as red blood cells, tumor cells, stem cells), etc.

The drug delivery system can carry the drug to the target and release the drug accurately to achieve better therapeutic effects and reduce drug side effects. At the same time, drug delivery systems can also maintain the stability of blood drug concentrations in organisms by controlling the release rate of drugs.

In recent decades, the rapid development of nanotechnology has led to the design and construction of nanoplatforms for a variety of biomedical applications for the diagnosis and treatment of diseases.

However, the nanocarriers used in current drug delivery systems generally have the disadvantages of low drug loading capacity and the inability to load macromolecular drugs. To this end, we developed nano-open hollow resin spheres (spilt SHS) with high drug-loading(drug delivery carriers) capacity and the ability to load macromolecule drugs.

As shown in the figure above, nano-open hollow resin spheres (SHS) have an open hollow sphere structure, the diameter is adjustable between 50-500nm, and the opening size is adjustable between 20-300nm. Nano-opening SHS have larger openings and can be loaded with macromolecular drugs. The hollow structure gives nano-open SHS a higher drug-loading capacity. The material of nano-open SHS is phenolic resin, which has good acid resistance, mechanical properties, heat resistance and good biocompatibility.Cells can engulf it, and it exhibits negligible toxicity. Moreover, it yields high carbonization rates in phenolic resin, and, if needed, one can prepare nano-opening hollow carbon spheres through high-temperature carbonization.

As shown in the figure below, the drug loading method we envision is to first load the drug through solution immersion centrifugation and solvent evaporation methods, then use the film hydration method to coat the drug-loaded nano-open SHS with lipids, and finally use The targeting and lymphatic orientation of liposomes brings the drug to the designated location for sustained release.